A case of ulcerative colitis with amyloidosis presenting as fever of unknown origin.

Amyloidosis is a disorder of protein metabolism which is characterized by deposition of eosinophilic material intercellularly which has characteristic ultra-structural morphology and biochemical features. Amyloidosis may be primary but more often it is secondary to various inflammatory, neoplastic and suppurative conditions. Inflammatory bowel disease is an unusual cause for secondary amyloidosis. The incidence of amyloidosis in Crohn’s disease varies from 1-8% ; however it is extremely rare in ulcerative colitis. We describe a case which was admitted to determine the cause for fever of unknown origin (F.U.O.) which turned out to be a case of secondary amyloidosis due to ulcerative colitis.